CRISPR AND CLEARR

We strive to make a difference – one base pair at a time.
after signed, sealed (6)
CLAMP crossover universe (14)
daughter of king lear (8)
doberman (14)
engraving (23)
faithfulness (17)
leatherface weapon (12)
not obvious; understated (22)
physicist of relative renown (18)
rule of thumb (1)
some monoids in a powerset (3)
type of cream cheese (6)
under the skin (20)
where millions listen to what Simon says (1)

CHANGEME